Fig. 6

GA-MSCs-mediated PD-L1 expression was attenuated by Ad5-Ki67/IL-15 in vitro. A and B Glioma cell GL261 cocultured with GA-MSCs with or without the virus for 72 h. Flow cytometry revealed that the virus could decrease PD-L1 expression in glioma cells despite the presence of GA-MSCs. C and D Human glioma cell 251. E and F Human glioma cell U87. G and H Human glioma cell BT-01. All data are presented as mean ± SD of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001