Fig. 2
Intramyocardial injection of MSCsTXL improved cardiac function, reduced infarct size and promoted angiogenesis after AMI. Representative images (A) of echocardiograms of rat heart and quantitative analysis (B) of LVEF, LVFS, LVEDV and LVESV (n = 8–10 for each group) at 28 days post-AMI. Representative images (C) and quantification (D) of the LV infarct size (n = 6) of transverse heart sections with Masson’s trichrome staining at 4 weeks after AMI. Scale bar = 2000 μm. Representative images of Sirius red staining (E) and quantification (F) of the collagen area. Scale bar = 2000 μm. Representative images of αSMA positively stained arterioles (G) or CD31 positively stained capillaries (I) at the border zone. Scale bar = 20 μm. Quantification of arteriole density (H) or capillary density (J) of the corresponding images of (G) or (I) (n = 5). Data were analyzed with one-way ANOVA followed by Tukey’s test and are shown as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001