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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Amphiregulin regulates odontogenic differentiation of dental pulp stem cells by activation of mitogen-activated protein kinase and the phosphatidylinositol 3-kinase signaling pathways

Fig. 5

The effects of AREG overexpression/knockdown on the differentiation of DPSCs. A Alizarin Red S staining showing mineralized nodule formation in the AREG ( +) and AREG (–) groups. B Quantitative analysis of A (n = 5, **P < 0.05). C Protein expression of odontoblastic markers DSPP, RUNX2, BSP, and OCN shown by Western blotting in the AREG ( +) group. The full-length gels and blots are included in Additional file 1: Fig. S1B. D ImageJ analysis of the gray level of the panel. E Protein expression of odontoblastic markers DSPP, RUNX2, BSP, and OCN shown by Western blotting in the AREG ( −) group. The full-length gels and blots are included in Additional file 1: Fig. S1C. F ImageJ was used to analyze the gray level of the panel. Data represent means ± SDs, n = 3, *P < 0.05, **P < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512