Skip to main content

Table 4 Results of lung function test in severe COVID-19 patients were followed at 3 months and 1 year

From: One-year follow-up study after patients with severe COVID-19 received human umbilical cord mesenchymal stem cells treatment

Parameter

Total patients (n = 25)

hUC-MSC (n = 8)

Control (n = 17)

1-year follow-up

3 Months

1 Year

P value

3 Months

1 Year

P value

3 Months

1 Year

P value

Control

hUC-MSC

P value

VC

VC (Mean ± SD)

2.91 ± 0.74

3.3 ± 0.81

0.055

2.72 ± 0.88

3.14 ± 0.93

0.102

3 ± 0.67

3.35 ± 0.84

0.144

3.35 ± 0.84

3.14 ± 0.93

0.575

VC (% of predicted)

81.4 ± 14.21

101.68 ± 15.84

0.000***

72.63 ± 9.86

99.75 ± 12.99

0.002**

85.53 ± 14.27

102.59 ± 17.31

0.003**

102.59 ± 17.31

99.75 ± 12.99

0.685

N, ≤ 80% predicted

11(44.0%)

1(4.0%)

0.001**

5(62.5%)

0(0%)

0.026*

6(35.3%)

1(6.9%)

0.085

1(6.9%)

0(0%)

1.000

FVC

FVC (Mean ± SD)

2.83 ± 0.75

3.02 ± 0.78

0.182

2.68 ± 0.89

2.8 ± 0.79

0.507

2.89 ± 0.7

3.12 ± 0.78

0.257

3.12 ± 0.78

2.8 ± 0.79

0.350

FVC (% of predicted)

80.04 ± 14.35

93.24 ± 11.27

0.000***

72.63 ± 9.46

89.88 ± 9

0.003**

83.53 ± 15.14

94.82 ± 12.12

0.022*

94.82 ± 12.12

89.88 ± 9

0.316

N, ≤ 80% predicted

13(52.0%)

3(12.0%)

0.002**

6 (75.0%)

0(0%)

0.007**

7(41.2%)

3(17.6%)

0.259

3(17.6%)

0(0%)

0.527

FEV1

FEV1 (Mean ± SD)

1.89 ± 0.71

2.54 ± 0.76

0.001**

2.12 ± 0.64

2.37 ± 0.73

0.193

1.78 ± 0.73

2.62 ± 0.78

0.002**

2.62 ± 0.78

2.37 ± 0.73

0.459

FEV1 (% of predicted)

65.84 ± 23.94

90.72 ± 10.97

0.000***

71.88 ± 8.46

89.13 ± 6.85

0.001**

63 ± 28.31

91.47 ± 12.57

0.001**

91.47 ± 12.57

89.13 ± 6.85

0.628

 ≤ 80% predicted

18(72.0%)

4(16.0%)

0.000 ***

6(75.0%)

0(0%)

0.007**

12(70.6%)

4(23.5%)

0.015*

4(23.5%)

0(0%)

0.283

FEV1/FVC (%)

0.67 ± 0.19

0.84 ± 0.07

0.000***

0.8 ± 0.08

0.84 ± 0.06

0.186

0.61 ± 0.2

0.83 ± 0.08

0.000

0.83 ± 0.08

0.84 ± 0.06

0.829

 ≤ 70%

12(48.0%)

1(4.0%)

0.000***

1(12.5%)

0(0%)

1.000

10(58.8%)

1(6.9%)

0.000

1(6.9%)

0(0%)

1.000

PEF

2.82 ± 1.83

4.44 ± 1.42

0.001

3.59 ± 1.81

4.17 ± 1.73

0.391

2.46 ± 1.78

4.58 ± 1.28

0.001

4.58 ± 1.28

4.17 ± 1.73

0.514

PEF (% of predicted)

38.4 ± 27.05

65.92 ± 18.8

0.000

45.5 ± 22.87

62.63 ± 20.03

0.034

35.06 ± 28.84

67.47 ± 18.62

0.001

67.47 ± 18.62

62.63 ± 20.03

0.559

MVV

70 ± 26.49

90.44 ± 25.23

0.005

71.56 ± 39.61

89.44 ± 35.4

0.241

69.26 ± 19.08

90.91 ± 20.14

0.011

90.91 ± 20.14

89.44 ± 35.4

0.895

MVV (% of predicted)

65.32 ± 15.52

86.74 ± 15.94

0.000

67.13 ± 20.16

85.31 ± 17.62

0.014

64.47 ± 13.46

87.41 ± 15.6

0.000

87.41 ± 15.6

85.31 ± 17.62

0.766

  1. VC vital capacity, FVC vital capacity, FEV1 forced expiratory volume in 1 s, PEF peak expiratory flow, MVV maximal voluntary ventilation
  2. *P < 0.05; **P < 0.01; ***P < 0.001