Fig. 4

PF-127/hADSCs-Exos improves cell proliferation and angiogenesis. a Images illustrate Ki67 immunohistochemistry staining on days 4 and 7. Scale bar = 20 μm. b Quantification of the number of Ki67 positive cells in the wound area. c α-SMA staining of myofibroblasts in wound bed days 4 and 7 post-operative. Scale bar = 20 µm. d Quantification of α-SMA stained tissues. e Representative images of IHC of CD31 on days 4 and 7 wound sections. Scale bar = 20 µm. f Microvessel density analyses of diverse treatment days 4 and 7 (n = 6). In b, d, and f, data are shown as mean ± SEM; n = 6 for each group. *p-value < 0.05, **p-value < 0.01, ***p-value < 0.001, ****p-value < 0.0001 vs vehicle control group