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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: IL-37 overexpression promotes endometrial regenerative cell-mediated inhibition of cardiac allograft rejection

Fig. 3

IL-37-ERCs decreased the infiltration of CD4+ cells while promoting Treg generation in the graft. A Representative graft sections for immunohistological staining of intra-graft CD4+ cell infiltration. The positive staining area was shown by an arrow. B The mononuclear cells were isolated from the grafts and analyzed by flow cytometry. Treg (CD4+Foxp3+ cell) populations were significantly raised in the ERC-treated group compared to the untreated and further increased in the IL-37-ERC-treated group (n = 6 per group). The percentage of intra-graft CD4+ cells (C) and Tregs (CD4+Foxp3+ cells) (D) from heart allografts of different groups. Data were analyzed with one-way ANOVA. *P < 0.05, **P < 0.01, ***P < 0.001, ns = non-significant. For all panels, the bar graphs represent mean ± SD

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