Fig. 7From: Mesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4Proposed model for the therapeutic roles of MSC-sEV in DR. MSC-sEV-delivered NEDD4 mediates the ubiquitination and degradation of PTEN, thus promoting the activation of AKT signaling pathway and upregulating NRF2 expression to alleviate the oxidative damage and apoptosis of RPE cellsBack to article page