Fig. 1

mRNAsi expression and associated key modules in human ICC. A Comparison of corrected mRNAsi in ICC patients with or without distant metastasis. B Volcano map of differentially expressed genes (DEGs). C Kaplan–Meier analysis of the overall survival of ICC patients in correlation with corrected EREG-mRNAsi expression in TCGA database. D Cluster dendrogram of genes in ICC patients; each color represents a co-expression module which contains a subgroup of highly connected genes. E Correlation between gene modules and mRNAsi scores (or EREG-mRNAsi scores); the correlation coefficient (left) and p value (right) were listed, respectively. F Scatter diagram for three important gene modules: the orange, magenta and light yellow module. (*p < 0.05)