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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Notch-activated mesenchymal stromal/stem cells enhance the protective effect against acetaminophen-induced acute liver injury by activating AMPK/SIRT1 pathway

Fig. 3

Notch-activated MSCs inhibit XBP1s/NLRP3 activation in APAP-induced liver injury. A Western blot analysis of XBP1s, NLRP3, ASC and C-caspase-1 expression in liver tissues from the indicated animals. B, C ELISA analysis of serum IL-1β and IL-18 levels (n = 5 mice/group). D Hepatic macrophages (Kupffer cells) were isolated from mice after APAP injection, with or without MSC-siNS + JAG1 or MSC-siNotch2 + JAG1 treatment. Western blot analysis of XBP1s, NLRP3, ASC and C-caspase-1 expression in Kupffer cells. Representative of three experiments. Data are presented as the mean ± SD. *p < 0.05, **p < 0.01

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