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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Embryonic stem cell-derived mesenchymal stem cells alleviate skeletal muscle injury induced by acute compartment syndrome

Fig. 8

Depletion of macrophages using LC attenuated the therapeutic effect of ESC-MSCs. a Immunohistochemical evaluation of macrophage (CD68) infiltration in skeletal muscle after macrophage depletion. b Representative images showing CD68, CD86, and CD206 expression in skeletal muscle after macrophage depletion. c Quantitative analysis of CD68 expression. d Quantitative analysis of CD86 expression. e Quantitative analysis of CD206 expression. f Quantitative analysis of CD206/CD86 ratio. g Representative images of skeletal muscle stained with H&E after macrophage depletion. h Quantitative analysis of skeletal muscle injury scores after macrophage depletion. i Serum CK levels after macrophage depletion. j Quantitative real-time PCR data showing the mRNA levels of TNF-α, IL-6, and IL-10 in skeletal muscle after macrophage depletion. N = 7. The data are presented as the mean ± SD. *P < 0.05 versus rats injected with LV

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Stem Cell Research & Therapy

ISSN: 1757-6512