Fig. 1

ApoE^−/− Fas^−/− mice showed atherosclerosis, SLE symptoms and increased MDSCs. Spleens and weights of spleens from B6 and ApoE^−/− Fas^−/− (AF) mice (A, B). Cervical lymph nodes and weights of cervical lymph nodes from B6 and ApoE^−/− Fas^−/− mice (C, D). Anti-ds DNA antibodies (E), proteinuria (F), creatinine (G) and IgG (H) in plasma from B6 and ApoE^−/− Fas^−/− mice. Representative hematoxylin and eosin (H&E)-stained images of kidney sections from B6 (I) and ApoE^−/− Fas^−/− mice (J). The plasma concentration of alanine aminotransferase (ALT) (K), triglycerides (TG) (L), total cholesterol (TC) (M), low-density lipoprotein (LDL) (N), high-density lipoprotein (HDL) (O) from B6 and ApoE^−/− Fas^−/− mice. Aortas from B6 and ApoE^−/− Fas^−/− mice stained with Oil Red O (P, Q). Representative H&E -stained images of liver sections from B6 and ApoE^−/− Fas^−/− mice (R). Representative flow cytometry results and percentages of MDSCs of blood (S), spleen (T) and cervical lymph nodes (U) from B6 and ApoE^−/− Fas^−/− mice. AF, ApoE^−/− Fas^−/− mice, n = 5 mice/group (A–R), n = 5 mice/group (S–U). Data were based on three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 using Student’s t-test