Fig. 3

Deletion of MDSCs ameliorated SLE and atherosclerosis in apoE^−/−Fas^−/− mice. The ApoE^−/−Fas^−/− mice were injected with anti-Gr1 or isotype IgG2b antibody, respectively. Schematic diagram of anti-Gr1 antibody treatment (A). The weights of spleens and cervical lymph nodes of ApoE^−/− Fas^−/− mice (B, C). IgG (D), anti-ds DNA antibodies (E), proteinuria (F), and creatinine (G) in plasma of ApoE^−/− Fas^−/− mice. Representative H&E and PAS-stained images of kidney sections from ApoE^−/− Fas^−/− mice (H–K). The plasma concentration of ALT (L), TG (M), TC (N), LDL (O) and HDL (P) in ApoE^−/− Fas^−/− mice. Aortas from ApoE^−/− Fas^−/− mice stained with Oil Red O (Q, R). Representative H&E -stained images of liver sections from ApoE^−/− Fas^−/− mice (S–V). AF, ApoE^−/− Fas^−/− mice, n = 5 mice/group, Data were based on three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 using Student’s t-test