Fig. 4

MSC transplantation alleviated lupus symptoms in apoE^−/−Fas^−/− mice. The ApoE^−/−Fas^−/− mice were injected with MSC or PBS via tail vein. Schematic diagram of MSC transplantation (A). Spleens and weights of spleens from ApoE^−/− Fas^−/− mice (B, C). Cervical lymph nodes and weights of cervical lymph nodes from ApoE^−/− Fas^−/− mice (D, E). Anti-ds DNA antibodies (F), IgG (G), proteinuria (H) and creatinine (I) in plasma of ApoE^−/− Fas^−/− mice. Representative H&E and PAS-stained images of kidney sections from ApoE^−/− Fas^−/− mice (J, K). Immune staining of deposition of C3 and IgG in kidney sections from ApoE^−/− Fas^−/− mice (L, M). AF, ApoE^−/− Fas^−/− mice, n = 5 mice/group, Data were based on three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 using Student’s t-test