Skip to main content
Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage

Fig. 4

HucMSCs-EVs exert anti-inflammatory effect by downregulating METTL3 expression in macrophages. A. Western blot analysis of IL-1β and cleaved caspase-1 levels in culture SN and pro-IL-1β, pro-caspase-1, and NLRP3 levels in cell lysates in each group. B. NLRP3 ubiquitination was analyzed in THP-1 cells with different treatments. C. Western blot analysis of METTL3 levels in cell lysates in each group. D. The m6A level of RNA in each group (n = 3). E. Western blot analysis of IL-1β and cleaved caspase-1 levels in culture SN and pro-IL-1β, pro-caspase-1, NLRP3, and METTL3 levels in cell lysates in each group. Data are presented as mean ± SD. ns, no significance; *p < 0.05; **p < 0.01; ***p < 0.001

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512