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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6/STAT3 pathway in macrophages

Fig. 7

Exosomal miRNA profiling of MSCs and identification of miR-148a as an important content of MSC-EXO. A Heatmap showing the top 100 MSC exosomal miRNAs of RNA-seq and GSE159814 based on their expression value. B Selection of miRNAs related to liver repair and regeneration. C Comparison of six liver regeneration-related exosomal miRNAs: miR-30a-5p, 26a-5p, 148a-3p, 125b-5p, 196b-5p, and 29a-3p between MSC and MSC-EXO by RT-PCR. D Serum miR-148a mRNA levels in healthy controls and patients with liver cirrhosis were measured by RT-PCR and normalized using U6 (n = 24). E, F The correlation of serum miR-148a levels with FIB-4 and APRI score in patients with liver cirrhosis

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Stem Cell Research & Therapy

ISSN: 1757-6512