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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Oxidative stress-induced endothelial cells-derived exosomes accelerate skin flap survival through Lnc NEAT1-mediated promotion of endothelial progenitor cell function

Fig. 5

The differential expression of Lnc RNAs in exosomes and proteins in the Wnt/β-catenin pathway. A The volcano plot represented the differential expression of lncRNAs. The blue dots represent the downregulated genes, while the red dots represent upregulated genes. B Heat map of differential expression of Lnc RNAs in H2O2-HUVEC-Exos and HUVEC-Exos. Red corresponds to upregulated LncRNAs, and green corresponds to downregulated LncRNAs. C Quantification of Lnc NEAT1 level in EPCs after cultured with PBS, HUVEC-Exos, or H2O2-HUVEC-Exos. D The β-catenin, c-myc and cyclin D1 protein levels in EPCs in control, HUVEC-Exos or H2O2-HUVEC-Exos group. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001 vs. control group

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Stem Cell Research & Therapy

ISSN: 1757-6512