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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: MiR-152-5p suppresses osteogenic differentiation of mandible mesenchymal stem cells by regulating ATG14-mediated autophagy

Fig. 7

A schematic diagram showing that miR-152-5p suppresses osteogenic differentiation of mandible mesenchymal stem cells by regulating ATG14-mediated autophagy. a In sham’ MMSCs-M, autophagy could reduce the elevated ROS and maintain the redox homeostasis. b In OVX’ MMSCs-M, the upregulated miR-152-5p has an inhibitory effect on autophagy by targeting Atg14 and ATG14 interacts with VPS34 and Beclin1 to form ATG14 complex which plays an important role in autophagic initiation, leading to alleviating autophagy activity. The decreased autophagy couldn’t attenuate the inhibitory effect of ROS on osteogenic differentiation

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