Fig. 4

Metabolic characteristics of HCM iPSC-CMs. Overview of changes in metabolic parameters measured in HCM iPSC-CMs and reported in the literature. Each data point represents a log10 fold change compared to control of a single parameter reported in a publication. The quantitative data were obtained from the text, figures or supplemental data of each publication. When the exact value could not be obtained from the publication or its supplements, the quantitative data were retrieved from direct communication with the corresponding author of the respective publication. When no response was received from the authors, the fold change was scored from the bar graphs in the respective study by two reviewers independently, and the mean of the independent assessments was entered as a data point. Circles represent original data, open triangles represent scored data. ADP adenosine diphosphate; GLA alpha-galactosidase A; MT-ND1/2 NADH-ubiquinone oxidoreductase chain 1/2; PCr phosphocreatine; TEM transmission electron microscope