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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Ectoderm-derived frontal bone mesenchymal stem cells promote traumatic brain injury recovery by alleviating neuroinflammation and glutamate excitotoxicity partially via FGF1

Fig. 3

RNA sequencing analysis of FbMSC-treated TBI group and TBI group. Representative photos of wound healing (a) and topical views of brains (b) from the indicated groups collected at days 4, 14, and 28 after TBI. Scale bar, 2 mm. Volcano maps (c) and heat map (d) of differentially expressed genes in FbMSC-treated TBI group and TBI group. e GO analysis showed enrichment in cellular component, molecular function and biological process. f KEGG analysis of enriched pathway in FbMSCs. Quantitative RT-PCR verified the expression genes related to neuroactive ligand-receptor interaction (g), IL-17 signaling pathway (h) and MAPK signaling pathway (i). (n = 3–4 mice per group; Data are presented as the mean ± standard error; *, **, ***, and **** indicate significance at p < 0.05, p < 0.01, p < 0.001, and p < 0.0001, respectively).

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