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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Exosomal miR-17-5p from adipose-derived mesenchymal stem cells inhibits abdominal aortic aneurysm by suppressing TXNIP-NLRP3 inflammasome

Fig. 3

ADSC-exo inhibited AAA progression and TXNIP-NLRP3 inflammasome activation in macrophages. A, B The H&E, Masson trichrome and EVG staining (A) and statistical analysis (B) of elastin degradation in mice. Scale bar: 600 μm. C–D Serum levels of IL-1β and IL-18. E–F Immunofluorescence analysis of TXNIP positive macrophages in AAA mice. Scale bar: 50 μm. G Identification of the primary murine macrophages by CD68. Scale bar: 100 μm. H, I Western blot and statistical analysis. J RT-qPCR analysis. Repetition = 3. A one-way ANOVA were performed to compare data between groups. *P value < 0.05, **P value < 0.01, ***P value < 0.001

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