Table 4 GSEA of KEGG pathway gene sets enriched in tECM and Col1 groups
KEGG pathway name | Gene set size | ES | NES | P-value | FDR |
|---|---|---|---|---|---|
KEGG gene sets enriched in tECM group | |||||
Oxidative phosphorylation | 131 | 0.67 | 2.37 | 0.00E+00 | 0.00E+00 |
Parkinson's disease | 127 | 0.66 | 2.36 | 0.00E+00 | 0.00E+00 |
Proteasome | 46 | 0.78 | 2.35 | 0.00E+00 | 0.00E+00 |
Alzheimer's disease | 165 | 0.54 | 2.00 | 0.00E+00 | 9.26E−04 |
DNA replication | 36 | 0.67 | 1.93 | 0.00E+00 | 2.69E−03 |
Huntington's disease | 180 | 0.52 | 1.92 | 0.00E+00 | 2.49E−03 |
Protein export | 24 | 0.71 | 1.90 | 0.00E+00 | 2.84E−03 |
RNA degradation | 59 | 0.57 | 1.82 | 0.00E+00 | 6.94E−03 |
Cell cycle | 123 | 0.52 | 1.81 | 0.00E+00 | 6.30E−03 |
Pyrimidine metabolism | 98 | 0.53 | 1.81 | 0.00E+00 | 6.18E−03 |
Spliceosome | 127 | 0.50 | 1.78 | 0.00E+00 | 7.30E−03 |
RNA polymerase | 29 | 0.62 | 1.71 | 0.00E+00 | 1.68E−02 |
Aminoacyl tRNA biosynthesis | 40 | 0.56 | 1.63 | 0.00E+00 | 3.13E−02 |
Ribosome | 88 | 0.48 | 1.63 | 8.58E−03 | 2.96E−02 |
N glycan biosynthesis | 46 | 0.50 | 1.50 | 9.93E−03 | 7.35E−02 |
Steroid biosynthesis | 17 | 0.69 | 1.65 | 1.07E−02 | 2.75E−02 |
Oocyte meiosis | 112 | 0.38 | 1.31 | 1.11E−02 | 2.01E−01 |
Ubiquitin-mediated proteolysis | 134 | 0.36 | 1.30 | 2.02E−02 | 1.99E−01 |
Riboflavin metabolism | 16 | 0.65 | 1.53 | 2.55E−02 | 6.55E−02 |
Nucleotide excision repair | 44 | 0.45 | 1.34 | 4.19E−02 | 1.82E−01 |
KEGG gene sets enriched in Col1 group | |||||
Calcium signaling pathway | 177 | − 0.54 | − 1.71 | 0.00E+00 | 9.22E−02 |
Complement and coagulation cascades | 69 | − 0.57 | − 1.62 | 1.39E−03 | 1.64E−01 |
Cell adhesion molecules cams | 133 | − 0.51 | − 1.58 | 0.00E+00 | 2.01E−01 |
Endocytosis | 181 | − 0.49 | − 1.56 | 0.00E+00 | 1.94E−01 |