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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Adipose-derived stromal cells reverse insulin resistance through inhibition of M1 expression in a type 2 diabetes mellitus mouse model

Fig. 5

Nondiabetic plasma or diabetic plasma-treated SVFs decrease M1 macrophages in adipose tissues of Leprdb/db mice. SVFs were harvested from the adipose tissue of Leprdb/db mice and treated with plasma from Lepr+/+ or Leprdb/db mice. Lepr+/+ or Leprdb/db plasma-treated SVFs were injected into the inguinal WAT of Leprdb/db mice. Lepr+/+ and Leprdb/db mice were also treated with PBS as controls. One week later, we conducted flow cytometry analysis to assess the frequency and number of CD11c+ and CD11b.+ M1 macrophages in the adipose tissue. N = 5/group. *p < 0.05

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