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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Adipose-derived stromal cells reverse insulin resistance through inhibition of M1 expression in a type 2 diabetes mellitus mouse model

Fig. 7

Nondiabetic plasma-treated SVFs decrease adipose tissue IL-33 expression, plasma CCL2 and adiponectin levels, and plasma DPP4 activity in diabetic mice. SVFs were harvested from the adipose tissue of Leprdb/db mice and then treated with plasma from Lepr+/+ or Leprdb/db mice. Lepr+/+ or Leprdb/db plasma-treated SVFs were injected into the inguinal WAT of Leprdb/db mice. Lepr+/+ and Leprdb/db mice were also treated with PBS as controls. A One week later, the adipose tissue was harvested and then subjected to ELISA to detect IL-33 expression. The blood was harvested to determine plasma CCL2 B and adiponectin C levels. D Leprdb/db mice were injected with increased numbers (1 × 107 and 2 × 107) of Lepr+/+ or Lepr.db/db plasma-treated SVFs, and the blood was harvested to measure plasma DPP4 activity. N = 5/group. *p < 0.05; **p < 0.01; ***p < 0.001

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