Skip to main content
Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Bone morphogenetic protein 4 rescues the bone regenerative potential of old muscle-derived stem cells via regulation of cell cycle inhibitors

Fig. 2

Old MDSCs exhibit a greater percentage of cells in the G0/1 phase and higher P16 and lower P18 expression, when compared to young MDSCs. A Propidium iodide (PI) staining of DNA detected by flow cytometry of young and old MDSCs. Percentage of cells in G0/1 phase is significantly higher while percentage of cells in G2/M is significantly lower in old MDSCs compared to young MDSCs (*P < 0.05). B qPCR analysis of P16 and P18. P16 mRNA expression is undetectable low in young MDSCs, but high in old MDSCs (**P < 0.01). P18 mRNA expression is significantly lower in old MDSCs than in young MDSCs (*P < 0.05)

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512