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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Bone morphogenetic protein 4 rescues the bone regenerative potential of old muscle-derived stem cells via regulation of cell cycle inhibitors

Fig. 6

BMP4 reverse aged-related decline in cell proliferation via regulating P18 and P16 after single BMP4/GFP transduction. A Doubling time for old MDSCs before and after BMP4 transduction. BMP4/GFP transduction decreased the population doubling time of old MDSCs. *P < 0.05. B qPCR for P18 in transduced and un-transduced MDSCs. BMP4 transduction significantly increased P18 expression for both young and old MDSCs. *P < 0.05, **P < 0.01. C Q-PCR for P16 in BMP4 transduced and un-transduced MDSCs. Young MDSCs did not express detectable P16 before and after BMP4 transduction. BMP4 transduction significantly decreased P16 expression in old MDSCs. *P < 0.05. D QPCR for P18 in transduced and un-transduced MDSCs cultured in proliferation medium or osteogenesis medium. *P < 0.05, **P < 0.01. E Q-PCR for P16 in transduced and un-transduced MDSCs cultured in proliferation medium or osteogenesis medium

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Stem Cell Research & Therapy

ISSN: 1757-6512