Fig. 5

Follow-up evaluation. Data are expressed as median values. Diabetic and transplanted animals (blue squares). Diabetic untransplanted animals (brown) diamonds). Normal and transplanted animals (orange triangles). Normal untreated controls (green circles). A Weight: There was a progressive loss of weight among the diabetic untransplanted animals until time of death. The weights of the other 3 groups were comparable throughout the observation period. B Glucose levels: After induction of diabetes, the blood glucose levels increased sharply and remained high among the nontransplanted mice while they were normalized within 2 weeks in the transplanted mice; thereafter, euglycemia was maintained and similar to those of controls. C Human insulin: Human insulin became measurable among the diabetic transplanted mice as well as the nondiabetic transplanted ones. It was not measurable among the diabetic untransplanted animals or the normal treated controls. D Mouse insulin: Following STZ-induction, mouse insulin levels decreased sharply among the diabetic transplanted or untransplanted animals. They remained measurable among the nondiabetic transplanted animals as well as the normal controls