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Table 1 Quantification (in %) of different organoids and organoids-containing pigmented areas cultured with high or low ATRA at day 90

From: All-trans retinoic acid modulates pigmentation, neuroretinal maturation, and corneal transparency in human multiocular organoids

Type of organoids

High ATRA

Low ATRA

% of organoids

% of pigmentated areas

n

% of organoids

% of pigmentated areas

n

Retina

57 ± 4

30 ± 6

115

56 ± 6

70 ± 3*

87

Cornea

40 ± 4

42 ± 4

81

12 ± 3*

76 ± 1*

18

RPE

3 ± 1

100

6

32 ± 2*

100

51

  1. Data presented as mean ± SD (quantification of 207 organoids (high ATRA) and 160 organoids (low ATRA) in 4 replicates). Values indicated with stars are significantly different from those in high ATRA by Student’s t test; *p < 0.05. n; the number of organoids
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Stem Cell Research & Therapy

ISSN: 1757-6512