Fig. 4
From: Role of TRPC6 in periodontal tissue reconstruction mediated by appropriate stress
MBMSCs in the 5 μm and 10 μm confined microenvironments. A In the 5 μm confined microenvironment, mBMSCs resisted compressive stimulation, which made the cells acquire a rounded shape. In the 10 μm confined microenvironment, the changes in the cytoskeleton were not obvious. With TRPC6 knockout, the ability of cells to resist compressive stimulation decreased; thus, the cell morphology exhibited a relaxed state. Scale bar, 20 μm. B The cell migration trajectory decreased with TRPC6 knockout, and TRPC6 knockout decreased the speed of cell migration in the 10 μm confined microenvironment. The results are expressed as the mean ± standard deviation of one independent experiment; N ≥ 2. **P < 0.01; ***P < 0.001; ns, P > 0.05