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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: miR-126-3p containing exosomes derived from human umbilical cord mesenchymal stem cells promote angiogenesis and attenuate ovarian granulosa cell apoptosis in a preclinical rat model of premature ovarian failure

Fig. 7

miR-126-3p-hucMSCs-exosomes exerted antiapoptotic and proangiogenic effects in rats with chemotherapy-induced POF. A. Representative images of the TUNEL apoptosis assay in the ovaries of each group (× 200). B. Representative images of PCNA immunohistochemistry staining in the ovaries of each group (× 200). C. Representative images of CD31 immunohistochemistry staining in the ovaries of each group (× 200). n = 10 for each group. D. Representative western blots of the angiogenic-related factors in the injured ovarian tissues at 4 weeks after miR-126-3p-hucMSCs-exosomes treatment. E. Quantification of the angiogenic-related factors in the different treatment group. F. Representative western blots of the apoptosis-related factors in the injured ovarian tissues at 4 weeks after miR-126-3p-hucMSCs-exosomes treatment. G. Quantification of the apoptosis-related factors in the different treatment group. *P < 0.05 for all figures. n = 10 for each group

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