Skip to main content
Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Effects of smoking on the tissue regeneration-associated functions of human endometrial stem cells via a novel target gene SERPINB2

Fig. 7

Cigarette smoke exposure significantly reduced the secretions of multiple cytokines and growth factors associated with toxic signaling networks. Antibody-based human growth factor arrays, in which the membrane was dotted with antibodies against 40 different proteins were used to detect cigarette smoke extract-induced changes in protein levels in conditioned media. The secretions of eight growth factors (AR, EGFR, IGF-1, M-CSF/CSF1, NT-4, PDGF-AA, TGFβ3, and VEGFR3) were markedly reduced by cigarette smoke extract (A, B). Relationships between these eight downregulated growth factors and exposure to toxicants were also assessed using the GEO database, which revealed the clear correlationship between the eight downregulated growth factors and exposure to various toxicants including smoking (C). Bar graphs represent the averages of three independent experiments. Significant differences are presented as *p < 0.05, **p < 0.005, and ***p < 0.001 (two-sample t test)

Back to article page