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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: How the mechanical microenvironment of stem cell growth affects their differentiation: a review

Fig. 3

Mechanical stimulation induces osteogenic differentiation of stem cells via the PIEZO pathway. Mechanical stimulation induces cilia, which causes Ca2+ to enter the cell via PIEZO, activating the Notch signalling pathway and upregulating osteogenic differentiation genes. Mechanical damage also phosphorylates p38 MAPK via the IL-1α receptor, activating the transcription factor CREBP, which binds to the PIEZO gene promoter and can upregulate PIEZO

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