Skip to main content
Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Human umbilical cord mesenchymal stem cell-derived exosomal miR-335-5p attenuates the inflammation and tubular epithelial–myofibroblast transdifferentiation of renal tubular epithelial cells by reducing ADAM19 protein levels

Fig. 3

miR-335-5p expression is promoted by human umbilical cord mesenchymal stem cell (hucMSC)-exosome treatment in TGF-β1-treated HK-2 cells. A Venn image showing the overlapping miRNAs in hucMSC-exosomes between GSE69909 and Wei X results. B Venn image showing the overlapping miRNAs between miRNAs in hucMSC-exosomes and in kidney fibrotic tissues. C The expression difference (fold-change) of miR-188-5p, miR-335-5p, and miR-423-5p is shown according to GSE69909, Wei X results, and GSE76549. D The expression of miR-188-5p, miR-335-5p, and miR-423-5p was measured by RT-qPCR in hucMSC-exosomes. Statistical analyses were performed by student's t test (n = 3). E The expression of miR-188-5p, miR-335-5p, and miR-423-5p was measured by RT-qPCR in TGF-β1-treated HK-2 cells. Statistical analyses were performed by student's t test (n = 3). F miR-335-5p expression was measured by RT-qPCR after hucMSC-exosome treatment in TGF-β1-treated HK-2 cells (n = 3). Statistical analyses were performed by one-way ANOVA, followed by Tukey’s multiple comparisons post hoc test. (*P < 0.05)

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512