Fig. 1

The structure and transcription factor complexes of RUNX1 and RUNX1-RUNX1T1 along with histone modifications at different states. Although RUNX1T1 does not bind directly with DNA, it assists the combination of RUNX1-RUNX1T1 with N-CoR and DNMTs to further recruit HDACs and transform from a co-activator to co-repressor complex. When the CRD binds with m-Sin3A and recruits HDACs, the histone is methylated and binds closer to DNA, tightening the chromosomal structure and leading to transcriptional silence