Fig. 2From: RUNX1T1 function in cell fateDynamic interaction among mediators of the RUNX1 and RUNX1-RUNX1T1 network. When interfering RUNX1-RUNX1T1 binds with siRNAs, genes that correspond to granulocytic differentiation or anti-renewal undergo upregulation. However, factors including FOXO1, JMJD1C, and SMAD3 are significantly activated to drive leukemic self-renewal or block myeloid differentiationBack to article page