Fig. 4

The effects of RUNX1T1 isoforms on adipogenesis via alternative splicing of RUNX1T1 mRNA. Adipogenesis covers the transition from mesenchymal precursors to fibroblasts and preadipocytes and the final differentiation into adipocytes. Overexpression of FTO leads to an increase in the RUNX1T1-S isoform, which promotes the process of cellular expansion by upregulating CCND1 and CCND3 and differentiation into mature adipocytes through interaction between PPARγ and C/EBP, as well as myogenesis inhibition