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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Exosome from indoleamine 2,3-dioxygenase-overexpressing bone marrow mesenchymal stem cells accelerates repair process of ischemia/reperfusion-induced acute kidney injury by regulating macrophages polarization

Fig. 3

Effect of MSCs-Exo-IDO on renal tubular cell proliferation in IRI mouse model. A On day 1, 3 and 7 after IRI, kidney tissues were collected from sham operation group, IRI model mice, MSCs-Exo-NC-treated IRI mice and MSCs-Exo-IDO-treated IRI mice (n = 3/group at each time). Subsequently, IHC staining was used to detect Ki67 expression and the rate of Ki67-positive cells in kidney tissues. Arrowheads indicated the ki67-positive cells. Scale bar: 20 μm. B Quantization diagram of panel A. The histogram is presented by Means ± SD. *P < 0.05; **P < 0.01

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