Fig. 1

Expression of HPGDS decreases in diabetic wound bed and deficiency of Hpgds delays wound healing. a Gene Ontology analysis of transcriptome data from Gene Expression Omnibus database. b Interaction network of differential expression. c Dynamic Hpgds mRNA expression in wound edge tissue from diabetic mice at 0, 1, 3, 7, 10 and 13 days. The data are presented as the mean ± SD. *P < 0.05; **P < 0.01. n = 3. Abbreviation: non-db, nondiabetic mice; d, day. d Representative images of the gross appearance of non-db excisional wounds with PBS, control siRNA or Hpgds siRNA (i). Scale bar = 0.5 cm, n = 5. Hpgds mRNA expression in wound edge tissue was detected at 3 days by qRT-PCR (ii). n = 5. The data are presented as the mean ± SD. **P < 0.01; ****P < 0.0001. CTL Control, means normal mice without wound, PBS Phosphate buffer saline