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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Overexpressing HPGDS in adipose-derived mesenchymal stem cells reduces inflammatory state and improves wound healing in type 2 diabetic mice

Fig. 4

hADSCHpgds promotes proliferation and vascularization. a Thickness of the healing skin. Hematoxylin and eosin staining for the sections of wound edge tissue at 14 days, n = 5. Yellow line indicates the healing edge; yellow arrows indicate the thickness of the healing skin including the epidermis and dermis. Scale bar = 200 μm. b Immunofluorescence staining of PCNA in the healing skin within one millimeter to the healing edge at 10 days. Blue, DAPI; green, PCNA; Average area of positive fluorescence per group was quantified. Scale bar = 100 μm. c Immunohistochemical staining for CD31 and Collagen-I in the healing skin within one millimeter to the healing edge at 14 days; Average number of positive cells and gray-scale value per group were quantified. Red arrows indicate vascular endothelial cells. Scale bar = 100 μm. d The mRNA expressions of VEGF and Collagen-I in the healing skin were quantified at 14 days. The data are presented as the mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001. n = 5. CTL Control, means treatment with PBS

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