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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Propofol enhances stem-like properties of glioma via GABAAR‐dependent Src modulation of ZDHHC5-EZH2 palmitoylation mechanism

Fig. 1

Propofol increases glioma growth by enhancing the stem-like properties of tumors. A GBM patient-derived xenografts (PDX; GBM0378) mouse model injected with low and standard doses of propofol by ex vivo bioluminescent assay. Quantification of bioluminescent photon intensity (n = 5 in each group). B Detection of GFAP, Sox2, and Oct4 in the tumor of a PDX mouse model injected with or without low or standard doses of propofol by western blot. C Detection of CD44 and CD133 in the tumor of a PDX mouse model injected with or without low or standard doses of propofol by flow cytometry. D Ex vivo bioluminescent assay comparing glioma growth in mice injected with propofol-treated or DMSO-treated glioma stem cells (GSCs). Quantification of bioluminescent photon intensity (n = 5 in each group). E Detection of glioma spheres formed for U118-dervied and LN18-dervied GSCs treated with or without propofol and cultured for a second passage. Scale bars, 100 μm. Quantification of glioma spheres formation capacity (n = 5 in each group). Ctrl, control; LD, low dose; and SD, standard dose

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