Fig. 4

Anti-inflammatory factor IL-1ra is necessary for AEC-SC-mediated amelioration on skin lesions of IMQ-induced psoriasis-like mice. a Representative phenotypic image of mouse back skin  after 6-day IMQ administration and different medium treatment. b Representative image of H&E staining of the back skin of mice in different groups. Scale bar: 50 μm. c Quantification of epidermal thickness of mice in different groups. d Immunostaining of lesion skin tissue with Ki67 antibody and the representative images are shown. Scale bar: 50 mm. e Qualification of the number of Ki67 positive cells for per field of the lesion skin tissue in different groups. f Relative mRNA levels of FLG, HENR and IVL in the lesion skin tissue of mice in different groups. The mRNA levels of genes in CON group were set as 1 and the data are expressed as the mean ± SEM, n = 3. *P < 0.05, **P < 0.01, ***P < 0.001