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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Irisin enhances chondrogenic differentiation of human mesenchymal stem cells via Rap1/PI3K/AKT axis

Fig. 2

Irisin activates the Rap1 and PI3K/AKT pathways. A The heatmap of DEGs, as detected by RNA-seq in hMSCs induced-cartilage tissue treated with and without irisin for 7 d (n = 3 biological replicates). B The volcano map of genes distribution. C GO terms with the most significant P values. BP: biological process, CC: cellular component, MF: molecular function. D GSEA of positively associated cartilage condensation process (Left panel) and cartilage condensation hallmark genes treated with irisin compared with vehicle (Right panel). E The top 20 of pathways enrichment by KEGG analysis. F The mRNA expression levels of key genes (RAP1A, RAP1B, RAP1GAP, SIPA1L2, RASGRP) in Rap1 signaling pathway. The concentration of irisin used in this figure was 100 ng/ml. *P < 0.05, **P < 0.01 compared to control

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