Fig. 6From: Irisin enhances chondrogenic differentiation of human mesenchymal stem cells via Rap1/PI3K/AKT axisSchematic diagram highlighting the primary findings of this study. Irisin up-regulates miR-125b-5p, targeting SIPA1L2 and activates the Rap1/PI3K/AKT signaling axis, and consequently promoted the expression levels of chondrogenic differentiation genes (COL2A1, ACAN, and SOX9), enhancing chondrogenic differentiation in hMSCs via integrin receptor.Back to article page