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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment

Fig. 3

Overexpression of circBIRC6 suppressed the osteogenic potential of PDLSCs in the inflammatory conditions. A Establishment of circBIRC6-overexpressing PDLSCs. B The ALP staining intensity of PDLSCs in the circBIRC6-overexpressing PDLSCs and control PDLSCs under the inflammatory microenvironment. C ARS staining of mineralized nodules formed by PDLSCs with indicated modifications. D–F qRT-PCR, immunoblot and immunofluorescence staining of osteogenic differentiation markers in PDLSCs with indicated modifications. Scale bar: 20 μm. Data are presented as the mean ± SD (**P < 0.01, ***P < 0.001)

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Stem Cell Research & Therapy

ISSN: 1757-6512