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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment

Fig. 8

CircBIRC6/miR-543 axis regulated the osteogenic potential of PDLSCs via PTEN/PI3K/AKT/mTOR signaling pathway. A, B WB assay of PTEN expression level in PDLSCs with indicated modifications. C The relative luciferase activities of PTEN promoter in PDLSCs transfected with circBIRC6 wt, circBIRC6 mut. miR-543 mimic and miR-543 inhibitor alone or in combination. D–F WB assays of PTEN, osteogenic differentiation markers, p-PI3K, PI3K, p-AKT, AKT, p-mTOR and mTOR in PDLSCs with indicated treatments. G Schematic illustration of the circBIRC6/miR-543/PTEN/PI3K-AKT-mTOR axis in regulating the PDLSC osteogenic differentiation under the inflammatory microenvironment. Data are presented as the mean ± SD (ns: not significant, *P < 0.05, **P < 0.01, ***P < 0.001)

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Stem Cell Research & Therapy

ISSN: 1757-6512