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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy

Fig. 6

SAHH overexpression improves cardioprotection of diabetic BMSCs. We further evaluated whether the overexpression of SAHH in BMSCs derived from diabetic rats can improve the therapeutic value of stem cells to DCM. Diabetic BMSCs with SAHH overexpression were infused 4 times. The LVEF (a) and E’/A’ ratio (b) were used to assess the cardiac function using echocardiography (n = 8). qPCR analysis showed the increased expression of cardiac stress-related genes, including Nppa, Nppb, and Myh7 (c) in rats with DCM (n = 4). Heart samples were harvested and fixed with paraformaldehyde. The immunofluorescence staining of vWF (d, e) and αSMA (f, g) was conducted to assess the pro-angiogenesis induced by BMSCs transplantation (n = 5). Sirius Red staining (h, i, n = 6) was conducted to assess to reflect myocardial fibrosis (scale bar = 100 μm). *P < 0.05 versus DCM group, #P < 0.05 versus DCM receiving diabetic BMSCs group.

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