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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy

Fig. 7

SAHH improves the biological activity of BMSCs partly by activating the Nrf2-mediated antioxidant signal . To further explore the underlying mechanism, we further explored whether SAHH activates the Nrf2-mediated antioxidant pathway to improve the activity and function of diabetic BMSCs. in vitro. The protein expression of Nrf2 and Keap1 was assessed in diabetic BMSCs after SAHH overexpression (a–c). After further treatment with ML385 (a Nrf2 inhibitor), the downstream molecules including anti-oxidative HO-1 (d, e), SOD1 (f), SOD2 (g), and pro-oxidative p67phox (h) were measured by western blots (n = 4). *P < 0.05 versus DM-BMSCs group, #P < 0.05 versus DM-BMSCs +SAHH group.

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Stem Cell Research & Therapy

ISSN: 1757-6512