Fig. 2
MSC-EVs improves visual function in rd10 mice. A Illustration of the optomotor system. B Quantification of the visual acuity in WT, NS-treated and MSC-EVs-treated rd10 mice. C Representative ERG traces under various light intensities ranging from 0.1 to 3.0 cd • s/m2 under dark adaptation in WT (blue), NS-treated rd10 mice (black) and MSC-EVs-treated rd10 mice (red) at P28. Arrowhead shows the starting time point of the flash. D, E Average peak amplitudes of dark-adapted a-wave (D) and b-wave (E). F Representative ERG traces at 10.0 cd • s/m2 flash under light adaptation with 20 cd • s/m2 background. G Average b-wave amplitudes of light-adapted condition in three groups. Data are represented as mean ± SEM. Student’s t test and one-way ANOVA test were applied. * P < 0.05, **, P < 0.01