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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Mesenchymal stem cell-derived extracellular vesicles protect retina in a mouse model of retinitis pigmentosa by anti-inflammation through miR-146a-Nr4a3 axis

Fig. 5

MSC-EVs regulate the gene expression of inflammatory cytokines in the rd10 retina. A A pie chart of RNA-seq results in WT, NS-treated and MSC-EVs-treated rd10 retinas showing the number of genes whose expression differs between the groups. B Heat map of RNA-seq results showing the 40 differentially expressed genes between NS-treated and MSC-EVs-treated rd10 retinas. C The expression level of 13 differentially expressed genes between NS-treated and MSC-EVs-treated rd10 retinas which are related to immunity and inflammation. D-G qPCR quantification of 4 differentially expressed genes between NS-treated rd10 and MSC-EVs-treated rd10 retinas. Data are represented as mean ± SEM. A Student’s t test was applied for qPCR data

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