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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Infusion of two-dose mesenchymal stem cells is more effective than a single dose in a dilated cardiomyopathy rat model by upregulating indoleamine 2,3-dioxygenase expression

Fig. 3

IDO-OE hUCMSC treatment attenuates cardiac inflammation and cardiac dysfunction in DCM rats. A Western blot analysis of IDO expression in the different groups of hUCMSCs. B–E Echocardiography analysis of both systolic (EF%, FS%) and diastolic (E/E′, IVRT) functions in DCM rats. F–I Flow cytometry analyses of the proportions of Tregs, Th2, Th1, and Th17 cells in the hearts of rats. J, K RT-qPCR analyses of the related mRNA transcript levels of the genes involved in Treg, Th2, Th1, and Th17 cell functions in the hearts of rats. L, M Cardiac IDO expression was assessed by Western blot and quantitatively analyzed. Data are mean ± SEM of each group (N = 3–5 rats per group) from at least three independent experiments. *P < 0.05, **P < 0.001, ***P < 0.001 by one-way ANOVA

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