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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Infusion of two-dose mesenchymal stem cells is more effective than a single dose in a dilated cardiomyopathy rat model by upregulating indoleamine 2,3-dioxygenase expression

Fig. 5

Treatment with IDO-OE hUCMSCs changes the frequency of different subsets of circulating CD4 + T cells in DCM rats. A, B Representative flow cytometry dot plots and quantitative analysis of peripheral blood Tregs in DCM rats at week 8 post-induction. C–E Quantitative analyses of Th1, Th2, and Th17 proportions in peripheral blood from DCM rats at week 8 post-induction. F–L The levels of serum IL-10, IFN-γ, IL-4, IL-17a, TNF-α, IL-6, and GM-CSF in individual rats at 8 weeks post-induction. Data are mean ± SEM of each group (N = 3–5 rats per group) from at least two independent experiments. *P < 0.05, **P < 0.001, ***P < 0.001 by one-way ANOVA

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